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Meistens profitieren jene Patientinnen und Patienten am meisten von der Therapie, die einen sehr niedrigen Hormonspiegel und sehr starke Beschwerden haben. Zu dem gehört auch die regelmässige Betreuung und Anpassung der Ersatzbehandlung, welche unseren Patientinnen und Patienten angeboten wird. Einen Wachstumshormonmangel im Erwachsenenalter festzustellen ist nicht einfach, da die hervorgerufenen Beschwerden unspezifisch sind. In der Regel untersuchen Endokrinologinnen und Endokrinologen Menschen auf den Mangel, die eine Erkrankung im Bereich der Hypophyse zeigen, die eine OP oder Bestrahlung hatten oder ein Schädel-Hirn-Trauma erlitten. Kongenitale Ursachen für einen isolierten Wachtumshormonmangel sind unter anderem Anomalien des Wachstumshormon-Releasing-Hormon-Rezeptors (GHRH-Rezeptor) oder Fehlbildungen des Zentralnervensystems.
In den späten 1990er und frühen 2000er Jahren struggle HGH in biosynthetischer Type jedoch hoch verfügbar und seitdem eines der gefragtesten Hormone sowohl in der Hormonersatztherapie als auch in der Welt der Leistungssteigerung. Mögliche Nebenwirkungen von Wachstumshormon sind Karpaltunnelsyndrom, Hyperglykämie, Schilddrüsenunterfunktion, Flüssigkeitsansammlung und erhöhter Blutdruck. Wachstumshormon hat anabole Wirkungen, die zu Muskelaufbau, Fettabbau und Knochenwachstum führen. Es hat auch positive Auswirkungen auf die Regeneration und Heilung von Gewebe. Es werden Bluttests durchgeführt, um festzustellen, ob zusätzliches Wachstumshormon benötigt wird und ob die Behandlung erhöht, verringert oder abgesetzt werden sollte. Auch der Cholesterinspiegel, der Blutzuckerspiegel und die Knochendichte werden überprüft, um zu sehen, ob sie gesund sind. Diese Episoden sind teilweise an den Schlaf gebunden, denn die Anzahl und die Amplitude (Spitzenwert) der Hormonausschüttung nehmen in den Tiefschlafphasen zu.
Über sämtliche anderen constructive Faktoren liegen weder Belege, noch wissenschaftliche Studien vor. Eine Erkrankung, die mit Wachstumshormonen behandelt wird, ist die Jakob Krankheit. Sie entsteht aufgrund einer fehlerhaften Erbinformation und wird in den meisten Fällen entweder durch eine Operation mit verunreinigtem OP-Besteck oder einer Bluttransfusion übertragen, kann aber auch erblich bedingt sein. Zu dem ersten Faktor gehört Insulin, wodurch es nicht zu einem erhöhten Spiegel kommt, sondern der Blutzuckerspiegel konstant gehalten wird, und bei dem es sich um ein Speicher-und Sättigungshormon handelt. Insulin wird als Reaktion nach einer Nahrungsaufnahme, mit verschiedenen Kohlenhydraten, in der Bauchspeicheldrüse ausgeschüttet. HGH unterstützt um Fettpolster zu mobilisieren, die Fettverbrennung anzukurbeln und magere Muskelmasse bestmöglich zu erhalten.
Der Wachstumshormon-Suppressions-Test wird durchgeführt, wenn Kinder Zeichen von Großwuchs, Erwachsene Zeichen von Akromegalie zeigen oder wenn der Verdacht auf Hypophysenüberfunktion besteht. Außerdem ist der Suppressions-Test angezeigt wenn Verdacht auf einen Hypophysentumor besteht und gemeinsam mit IGF-I und anderen Hormonen, um die Effektivität einer Behandlung dieser Erkrankungen zu kontrollieren. Diese Kontrollen können in regelmäßigen Abständen über mehrere Jahre notwendig sein, um eventuelle Rückfälle frühzeitig zu erkennen. Die Untersuchung des Wachstumshormons kommt außerdem in Betracht, um die langfristigen Auswirkungen einer Chemotherapie im Kindesalter auf die Funktion der Hypophyse zu kontrollieren. Eine Überproduktion des Wachstumshormons entsteht meist durch einen in der Regel gutartigen Tumor der Hypophyse.
Nach einer mehrwöchigen Einnahme von 4 IE und mehr kann es bei einigen Personen zu Nebenwirkungen von Somatropin kommen. Dabei kann es sich um leichte Wassereinlagerungen handeln, die sich in den Fingern, Zehen und im Gesicht bemerkbar machen. Manchmal spüren manche Menschen auch ein Kribbeln in den Fingern und in den Handflächen. Diese Symptome treten auf, wenn ein Anwender unter dem Karpaltunnelsyndrom leidet. Hormonelle Medikamente, die für anabole Zwecke verwendet werden, können zu irreversiblen Wirkungen führen. Daher ist es notwendig, die möglichen Folgen des Konsums synthetischer Wachstumshormone nüchtern zu erkennen. Im Allgemeinen sollten Medikamente zum Aufbau von Muskelmasse nur von Profisportlern und unter Aufsicht eines Arztes angewendet werden.
Laut der Drug Enforcement Administration (DEA) wird HGH am häufigsten von Sportlern, Bodybuildern und alternden Erwachsenen missbraucht. Die Welt-Anti-Doping-Agentur und das Internationale Olympische Komitee betrachten HGH als leistungssteigernde Droge, deren Verwendung Athleten untersagt ist. Einmal ausgeschüttet, bleibt HGH für einige Minuten im Blutkreislauf aktiv, was der Leber gerade genug Zeit gibt, es in Wachstumsfaktoren umzuwandeln. Der wichtigste ist der insulinähnliche Wachstumsfaktor (IGF-1), der wachstumsfördernde Eigenschaften auf jede Zelle im Körper hat. Die Anwendung von Somatropin bei Menschen ohne vorliegenden Mangel kann zu Akromegalie mit schwersten Nebenwirkungen führen, die oft irreversibel sind. Somatropin oder Somatotropin (auch Somatotropes Hormon genannt) ist ein Proteohormon, das als Wachstumshormon im menschlichen und tierischen Organismus vorkommt und im Gehirn im Vorderlappen der Hypophyse gebildet wird.
Nach 7 Jahren betrug die Wachstumsgeschwindigkeit bei 26 Patienten im Mittel 5,31 ± 1,68 (SD) cm/Jahr, und die mittlere Körperhöhen-SDS lag bei zero,forty four ± 0,96 [35]. Einzelbestimmungen des Wachstumshormons lassen nur bei deutlichen Veränderungen eine Aussage zu, weshalb meist Funktionstests durchgeführt werden. Da es sich bei Wachstumshormon keinesfalls um eine harmlose oder wirkungslose Substanz handelt, muss vor der Anwendung von hGH bei älteren Menschen außerhalb zugelassener Indikationen gewarnt werden. Nicht aus placebokontrollierten Studien gewonnene Daten müssen kritisch interpretiert werden und dürfen nicht als Grundlage für den Einsatz eines Medikamentes in einer nicht zugelassenen Indikation gelten. Neue Indikationen dürfen nicht primär durch breite Anwendungsbeobachtungen propagiert werden, sondern müssen sachgerecht klinisch geprüft werden.
Hormonbooster sind Nahrungsergänzungsmittel, die die Wirkung von Hormonen verstärken können. Die am häufigsten von Sportlern verwendeten Booster sind Testosteron-Booster und Wachstumshormon-Booster. Natürliche Stimulatoren der Wachstumshormonsekretion sind unter anderem Peptide, Imbutomoerin, bestimmte Medikamente, Nährstoffe wie Niacin und L-Dopa, ausreichender Schlaf und körperliche Aktivität. Wachstumshormon wird im Sport, insbesondere im Bodybuilding, eingesetzt, um die Muskelmasse zu erhöhen, den Fettanteil zu reduzieren und die Erholung nach Verletzungen zu beschleunigen.
Tägliches schweres Coaching über Stunden führt langfristig zu Übertraining. Belastungen welche die körpereigene Regernationsfähigkeit übersteigen können das Gegenteil bewirken. Deshalb ist es wichtig auch auf Schlaf, die Ernährung und ausreichend Regeneration zu achten. Je intensiver das Coaching desto höher die Ausschüttung und Produktion des Wunderhormones.
Einige Patienten benötigen möglicherweise zusätzliche Insulin oder Medikamente, die die Bauchspeicheldrüse stimulieren. STH (Somatropes Hormon, Somatotropin) wird bei Wachstumsstörungen gemessen, also entweder bei sehr kleinwüchsigen (bzw. langsam wachsenden) oder ungewöhnlich großen (bzw. schnell wachsenden) Kindern, um die Ursache abzuklären. Auch Erwachsene, deren Akren sich auffällig vergrößern, kann eine Wachstumshormon-Analyse sinnvoll sein.

References:

https://ariaqa.com/employer/menschliches-wachstumshormon-nicht-indizierte-anwendung-von-hgh-in-der-sportmedizin-mit-risiken-verbunden/

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